Adjusting your prospecting to a new department

I started a new role a in May and am selling to a new department.

At my previous company, I'd say that cold prospecting via targeted emails was a huge strength of mine (my cold call skills are about even). I assumed the cold emailing would carry over as well. The targeted emails I'm sending that would usually result in meetings aren't getting any responses.

I'm trying to isolate whether it's my messaging, targeting, or if email is just not effective for this role.

How has the rest of the WR adjusted their prospecting methods when selling to new departments/personas?